0704-883-0675     |      dataprojectng@gmail.com

EVALUATION OF THE DISSOLUTION AND OTHER CHARACTERISTICS OF CYCLODEXTRIN MOLECULAR INCLUSION COMPLEXES OF ARTEMETHER

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

The present study aimed to improve the dissolution rate, solubility and ultimately, bioavailability of poorly soluble artemether, an antimalarial drug, through inclusion complex formation with hydroxypropyl-β-cyclodextrin. The solid complexes of artemether and hydroxypropyl-β-cyclodextrin (HP-β-CD) were prepared at a molar ratio of 1:1, 1:2 and 1:3 by kneading method. The effect of HP-β-CD on the aqueous solubility and dissolution rate of artemether was investigated through phase solubility analysis and in-vitro dissolution studies. The formation of inclusion complexes between artemether and HP-β-CD was confirmed by Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). The inclusion complex containing artemether: HP-β-CD (1:1 M) was further formulated into tablets by direct compression. The prepared tablets were evaluated for various pharmaceutical characteristics; crushing strength, friability, drug content and in-vitro dissolution profiles. Phase solubility diagram for the complex formation between artemether and HP-β-CD in water at 37 oC indicated the AL type, with an apparent stability constant KC found to be 143 M -1 . FT-IR spectroscopy and DSC confirmed the true inclusion of artemether into the cyclodextrin cavity. Prepared inclusion complex tablets exhibited higher and faster dissolution rate than the pure drug and marketed products. It was observed that the inclusion complex tablet showed a 3.9-fold increase in the amount of drug released in 15 min compared to the plain drug, 1.8-fold increase compared to the marketed brand – Lumartem® and 1.6-fold increase compared to Coartem® . At 120 min, none of the marketed tablets released up to 90 % of the drug, but the inclusion complex tablet achieved 90 % drug release viii in 31 min. The results of stability studies revealed no change in physical appearance and drug content over a reasonable period (ten weeks for short term stability test and 72 h for accelerated stability test), thus indicating that the formulation was stable. The result of the study shows that complexation of artemether by cyclodextrins is a good approach to enhance the solubility and dissolution rate of the drug.




FIND OTHER RELATED TOPICS


Related Project Materials

DUTY OF CARE: ITS IMPLICATIONS TO THE MEDICAL PROFESSION IN NIGERIA.

ABSTRACT

The Medical field is one of the most referred and reverenced profession in that it deals with the lives of huma...

Read more
AUDIT QUALITY AND CONCEPT OF GOING CONCERN IN QUOTED NON-FINANCIAL FIRMS IN NIGERIA

ABSTRACT

The objective of the study is to examine audit quality and concept of going concern in quoted nonfinancial companies in Nigeria....

Read more
THE IMPACT OF APPRENTICESHIP PROGRAMS ON VOCATIONAL SKILL ACQUISITION

ABSTRACT: The Impact of Apprenticeship Programs on Vocational Skill Acquisition investigates the effectiveness of apprenticeship programs in enhanc...

Read more
AN APPRAISAL OF ALIENATION OF RIGHT OF OCCUPANCY UNDER THE NIGERIAN LAW: ISSUES AND CHALLENGES

ABSTRACT

One of the problems this research discovers is that of conflict of interpretation of the requirement of consent provision as pro...

Read more
EXAMINING THE IMPACT OF EARLY CHILDHOOD EDUCATION ON ENTREPRENEURIAL MINDSET

 ABSTRACT: Examining the impact of early childhood education on entre...

Read more
IMPACT OF BRANDING AND PACKAGING ON SALES TURNOVER OF NESTLE FOOD NIGERIA PLC

INTRODUCTION
One element that has undergone tremendous change in the past decade is branding and packaging...

Read more
THE EFFECT OF CLASSROOM MANAGEMENT ON THE ACADEMIC ACHIEVEMENT OF PUPILS IN PRIMARY SCHOOLS

STATEMENT OF THE PROBLEM

Classroom management is the heart of any educational system. No curriculum Planning is complete...

Read more
ASSESSMENT OF PRINCIPALS’ SUPERVISORY PRACTICE ON TEACHERS’ ROLE PERFORMANCE IN JUNIOR SECONDARY SCHOOLS IN NIGERIA

ABSTRACT

This study assessed the Principals‟ Supervisory Practice on Teachers‟ Role Performance in Junior Secondary Schools in Kaduna Sta...

Read more
INFLUENCE OF GOVERNMENT OWNERSHIP ON POLITICAL CONTENTS OF BROADCASTING SERVICE

ABSTRACT

This study was carried out to examine the influence of government ownership on political...

Read more
AN INVESTIGATION INTO PERCEPTION AND ACCEPTANCE OF CAESAREAN SECTION AMONG PREGNANT WOMEN

BACKGROUND OF STUDY
In the majority of underdeveloped nations, including Nigeria, maternal mortality is th...

Read more
Share this page with your friends




whatsapp