0704-883-0675     |      dataprojectng@gmail.com

EVALUATION OF THE DISSOLUTION AND OTHER CHARACTERISTICS OF CYCLODEXTRIN MOLECULAR INCLUSION COMPLEXES OF ARTEMETHER

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 3000

ABSTRACT

The present study aimed to improve the dissolution rate, solubility and ultimately, bioavailability of poorly soluble artemether, an antimalarial drug, through inclusion complex formation with hydroxypropyl-β-cyclodextrin. The solid complexes of artemether and hydroxypropyl-β-cyclodextrin (HP-β-CD) were prepared at a molar ratio of 1:1, 1:2 and 1:3 by kneading method. The effect of HP-β-CD on the aqueous solubility and dissolution rate of artemether was investigated through phase solubility analysis and in-vitro dissolution studies. The formation of inclusion complexes between artemether and HP-β-CD was confirmed by Fourier transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). The inclusion complex containing artemether: HP-β-CD (1:1 M) was further formulated into tablets by direct compression. The prepared tablets were evaluated for various pharmaceutical characteristics; crushing strength, friability, drug content and in-vitro dissolution profiles. Phase solubility diagram for the complex formation between artemether and HP-β-CD in water at 37 oC indicated the AL type, with an apparent stability constant KC found to be 143 M -1 . FT-IR spectroscopy and DSC confirmed the true inclusion of artemether into the cyclodextrin cavity. Prepared inclusion complex tablets exhibited higher and faster dissolution rate than the pure drug and marketed products. It was observed that the inclusion complex tablet showed a 3.9-fold increase in the amount of drug released in 15 min compared to the plain drug, 1.8-fold increase compared to the marketed brand – Lumartem® and 1.6-fold increase compared to Coartem® . At 120 min, none of the marketed tablets released up to 90 % of the drug, but the inclusion complex tablet achieved 90 % drug release viii in 31 min. The results of stability studies revealed no change in physical appearance and drug content over a reasonable period (ten weeks for short term stability test and 72 h for accelerated stability test), thus indicating that the formulation was stable. The result of the study shows that complexation of artemether by cyclodextrins is a good approach to enhance the solubility and dissolution rate of the drug.




FIND OTHER RELATED TOPICS


Related Project Materials

EXPLORING THE LINK BETWEEN EARLY CHILDHOOD EDUCATION AND EXECUTIVE FUNCTION

Abstract: This study explores the link between early childhood education (ECE) experiences and the developme...

Read more
STATISTICAL MODELING AND OPTIMIZATION OF CARBON SEQUESTRATION BY ABSORPTION USING AQUEOUS AMMONIA

Statement of the Problem

The aggressive exploitation of fossil fuels and other natural resources has contaminated the air we breathe, the...

Read more
SURVEY OF DIVORCE AMONG WOMEN AND IT’S EFFECTS ON CHILDREN’S ACADEMIC ACHIEVEMENT

Abstract

Marriage is part of our daily lives, through marriage new right, roles and new social relation...

Read more
TWITTER BAN IN NIGERIA: A SCANDAL TO DEMOCRACY  

ABSTRACT

The basic aim of this study is to critically portray the erratic decision of twitter ban in Nigeria as...

Read more
DESIGN AND IMPLEMENTATION OF AN EXPERT MANAGEMENT SYSTEM FOR AUTOMOBILE FAULT DETECTION

OBJECTIVES OF THE STUDY

To develop an expert system on car maintenance and troubleshooting that is capable of assisting...

Read more
INVESTIGATION OF OCCUPATIONAL SAFETY AND HEALTH(OSH) COMPLIANCE LEVEL IN ADDRESSING COVID 19 PANDEMIC IN THE INDUSTRIAL SECTOR

BACKGROUND OF THE STUDY

In December 2019, the global population will be awoken to an outbreak of a dise...

Read more
IMPROVING PRODUCTIVITY IN THE CONSTRUCTION INDUSTRY THROUGH HUMAN RESOURCES DEVELOPMENT

Background To The Study

Human Resource Management (HRM) is of strategic importance in all organizations. It contributes...

Read more
UTILIZATION OF CAPITAL BUDGETING AS AN OPTIMAL TOOL FOR INVESTMENT ANALYSIS IN MANUFACTURING COMPANIES IN ENUGU AND ANAMBRA STATES

INTRODUCTION

Background of the Study

A company is a form of business organization, a corporate body or a corpo...

Read more
THE EFFECTIVENESS OF INDUSTRY MENTORSHIP PROGRAMS IN VOCATIONAL SECTORS

Abstract: The effectiveness of industry mentorship programs in vocational sectors is a crit...

Read more
DESIGN AND IMPLEMENTATION OF WEB BASED TIME TABLE SYSTEM FOR COMPUTER SCIENCE DEPARTMENT

PROBLEM DEFINITION

The scheduling problem can be defined as a problem of finding the optimal sequence for evaluating a f...

Read more
Share this page with your friends




whatsapp